Search Result of "Meeinkuirt, W"

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ที่มา:วิทยาสารเกษตรศาสตร์ สาขา วิทยาศาสตร์

หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Association between Haplotype Tagging Single Nucleotide Polymorphisms of the ret proto-oncogene (RET) and Hirschsprung Disease in Thais)

ผู้เขียน:ImgTheerawut Phusantisampan, ImgSurasak Sangkhathat, ImgWeeradej Meeinkuirt, ImgMalinee Sriariyanun

สื่อสิ่งพิมพ์:pdf

Abstract

Hirschsprung disease (HSCR) is one of several considerably complex diseases. Several HSCR susceptibility loci have been reported through genome-wide association studies. However, haplotype tagging single nucleotide polymorphisms (htSNPs) of the ret proto-oncogene (RET) has been identified in the past as being associated with an increased risk for HSCR. This study genotyped 10 single nucleotide polymorphisms (SNPs) of the RET in 68 patients with HSCR and 120 controls using TaqMan SNP genotyping assays and restriction fragment length polymorphism. However, haplotype analysis of the RET was likewise associated with the disease which has been suggested to be more powerful than individual SNP analyses. The haplotype analysis was carried out using Haploview software. The results showed that htSNPs, located in the intron 1 of the RET, strongly associated with HSCR (odds ratio 3.64, 95% confidence interval 2.24–5.92, P < 0.0001). These findings suggested that RET plays a role in the pathogenesis of HSCR in the Thai population.

Article Info
Agriculture and Natural Resources -- formerly Kasetsart Journal (Natural Science), Volume 049, Issue 1, Jan 15 - Feb 15, Page 103 - 110 |  PDF |  Page 

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Researcher

ดร. พรรณวิมล ตันหัน, ผู้ช่วยศาสตราจารย์

ที่ทำงาน:ภาควิชาเภสัชวิทยา คณะสัตวแพทยศาสตร์ บางเขน

สาขาที่สนใจ:Environmentat Toxicology

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