ที่มา:วิทยาสารเกษตรศาสตร์ สาขา วิทยาศาสตร์

หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Blood Chemistry Profile and Cardiac Troponin T Concentration in Thai Stray Dogs Infected with Heartworms)

ผู้เขียน:นางชูศรี ศรีเพ็ญ, ผู้ช่วยศาสตราจารย์, ML.Narudee Kasemsant, ดร.สันติ แก้วโมกุล, ผู้ช่วยศาสตราจารย์, นายโฆษิต ศรีเพ็ญ, อาจารย์

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Abstract

To investigate blood chemistry profile and to determine levels of myocardial marker proteins in canine dirofilariasis, measurements of biochemical parameters in liver and renal profile as well as the activity of the enzyme creatine kinase (CK) and cardiac troponin T (cTnT) concentration were performed on 72 Thai stray dogs with and without the presence of heartworms. The results showed that, with the exception of the low levels of gamma-glutamyl transferase (GGT) and uric acid, levels of other blood chemistry variables are comparable to those obtained from human subjects. The relatively high activity of CK observed was probably due to skeletal muscle injury occurred during restraint of animals. The majority of dogs, on the other hand, exhibited virtually non-detectable cTnT concentration comparable to those observed in apparently healthy persons. Furthermore, there was no statistically significant difference in cTnT levels between asymptomatic dogs with and without the presence of heartworms. These results may provide a basis for future clinical studies on assessing the extent of myocardial cell damage in symptomatic heartworm disease.

Article Info

Agriculture and Natural Resources -- formerly Kasetsart Journal (Natural Science), Volume 033, Issue 2, Apr 99 - Jun 99, Page 251 - 257 |  PDF |  Page

ที่มา:วิทยาสารเกษตรศาสตร์ สาขา วิทยาศาสตร์

หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Influence of Training Exercise on Clinical Plasma Chemistry Parameters and Cardiac Markers in Race Horses)

ผู้เขียน:นางชูศรี ศรีเพ็ญ, ผู้ช่วยศาสตราจารย์, Anuchit Sitthichaiyakul, Yuwadee Kongpiromchean, นายโฆษิต ศรีเพ็ญ, อาจารย์

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Abstract

Physiological variations of clinical chemistry parameters as a function of exercise reflecting general health and performance are largely unknown in race horses. To assess changes in blood biochemical variables, with special emphasis on cardiac markers, blood samples were drawn from twelve healthy race horses (6 males and 6 females; age range from 2 to 6 years) before and after the exercise training. Biochemical parameters in the renal, liver and lipid profile as well as the muscle enzymes creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were measured with standard methods using an automated analyzer Hitachi 917 (Roche Diagnostics). Cardiac troponin I (cTnI) plasma concentrations were analyzed with immunometric luminescence technology utilizing an automated immunoassay analyzer Vitros ECi (Ortho-Clinical Dianostic). With the exception of triglycerides, all other biochemical variables showed increased levels after the exercise, with values for alanine aminotransferase (ALT), albumin and total protein reaching statistical significance. The activities of CK and LDH, but not of AST, also displayed a significant increase after the training. Comparing with pre-exercise mean value of 0.015 ng/ml, a more than 10 fold increase in cTnI concentration (0.177 ng/ml) was observed, with a maximum value as high as 0.498 ng/ml. The majority of animals (58%) showed levels exceeding lower cut-off concentration of cTnI at 0.12 ng/ml indicative of a small myocyte injury. In conclusion, small changes in levels of the routine blood chemistry parameters due to training exercise are common in race horses. There was biochemical evidence of minor myocardial cell damage as assessed by cardiac troponin I plasma concentrations.

Article Info

Agriculture and Natural Resources -- formerly Kasetsart Journal (Natural Science), Volume 041, Issue 3, Jul 07 - Sep 07, Page 478 - 483 |  PDF |  Page