ที่มา:Steroidsหัวเรื่อง:Further study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agents |
ที่มา:Steroidsหัวเรื่อง:Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies |
ที่มา:Steroidsหัวเรื่อง:Synthesis of cytotoxic novel 9,11-secosterol analogs: Structure/activity studies |
ที่มา:Steroidsหัวเรื่อง:First synthesis of 3,16,20-polyoxygenated cholestanes, new cytotoxic steroids from the gorgonian Leptogorga sarmentosa |
|
|
ผลงานตีพิมพ์ในวารสารวิชาการFurther study on synthesis and evaluation of 3,16,20-polyoxygenated steroids of marine origin and their analogs as potent cytotoxic agentsผู้แต่ง:Bunyathaworn, P, Boonananwong, S, Dr.Boonsong Kongkathip, Emeritus Professor, Dr.Ngampong Kongkathip, Emeritus Professor, วารสาร: |
|
|
ผลงานตีพิมพ์ในวารสารวิชาการChanges in Sex Steroids, Growth Hormone, and Insulin-Like Growth Factor-I during Ovarian Development in Rainbow Trout Cultured in a Water Recirculating System with Continuous Lightผู้แต่ง:Gregory M. Webber, John W. Davidson, P. Brett Kenney, Christopher M. Good, Meghan L. Manor, Carla Welsh, Dr.Aunchalee Aussanasuwannakul, Steven T. Summerfelt, วารสาร: |
|
|
|
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Synthesis and Biological Evaluation of 3,16,20-Polyoxygenated Steroids of Marine Origin and Their Analogs) ผู้เขียน:สุธินี บุญอนันต์วงศ์, ดร.บุญส่ง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ, ดร.งามผ่อง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ สื่อสิ่งพิมพ์:pdf AbstractThe natural polyoxygenated steroids (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)- 16,20-dihydroxycholestan-3-one (2), (20S)-20-hydroxycholest-1-ene-3,16-dione (3) and (20S)-20- hydroxycholest-4-ene-3,16-dione (4), isolated from the gorgonian, Leptogorgia sarmentosa and unnatural analogs (5) (6), (12) and (13) were synthesized from tigogenin. Antitumor activity against three tumor cell lines (breast cancer, MCF 7, lung cancer NCI and oral cancer KB) was evaluated. Two compounds (3 and 4) containing ?,?-unsaturated ketone at ring A showed strong activity against NCI-H 187 (IC50 2.55, 4.35 ?g/ml) and moderate activity against MCF 7 and KB, the IC50 being in the range 12.69 – 19.55 ?g/ml whereas the analog quinone steroid 5 showed moderate activity against all tested cells. Compound 1 containing a keto group at C-3 and a hydroxyl group at C-16 showed moderate activity against NCI (IC50 17.84 ?g/ml), but was inactive against MCF 7 and KB, whereas compound 2 showed no activity against all tested cells. Cholestane (6) with dihydroxyl groups at C-3 and C-16 showed moderate activity against NCI-H 187 and KB the IC50 being in the range 10.22-11.04 ?g/ml, but was weakly active against MCF 7 (IC50 50.0 ?g/ml). The aromatic cholestane 13, the analog of 6 was strongly active against KB (IC50 4.69 ?g/ml), weakly active against MCF 7 (IC50 38.2 ?g/ml) and inactive against NCI-H 187 cell lines. Surprisingly compound 12 containing on unsaturated side chain was inactive with all tested cells. |
|
|
ที่มา:Shanghai Institute of Organic Chemistry, Republic of Chinaหัวเรื่อง:Synthesis of 3,6,20-Polyoxygenated Steroids of Marine Origin: Structure/Activity Studies. |
|
|
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Synthesis and Cytotoxicity Studies of Polyhydroxysterols and Their Sulfate Analogs) ผู้เขียน:Potjamarn Bunyathaworn, ดร.บุญส่ง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ, ดร.งามผ่อง คงคาทิพย์, ศาสตราจารย์เกียรติคุณ สื่อสิ่งพิมพ์:pdf AbstractThe six new polyhydroxy steroids, 3?, 20(S)-dihydroxy-5?-cholest-24-ene (19), 3?, 20(S)- dihydroxy-5?-cholestane (20), 3?, 20(S), 24-trihydroxy-5?-cholestane (23), 2?, 3?, 20(S)-trihydroxy- 5?-cholestane (29), 2?, 3?, 20(S)-trihydroxy-5?-cholest-24-ene (31), 2?, 3?, 20(S), 24-tetrahydroxycholestane (37) and the sulfate derivative 21 were synthesized from tigogenin. Antitumor activity against two tumor cell lines (lung cancer NCI-H187 and oral cancer KB) was evaluated. Compound 23 containing trihydroxy groups at the C-3, C-20 and C-24 positions showed strong activity against both NCI-H187 and KB cells (IC50 2.11 and 5.39 ?g/mL). The 3, 20-dihydroxy steroid 19 showed strong activity against NCI-H187 (IC50 4.24 ?g/mL) but was weakly active against KB (IC50 39.12 ?g/mL) whereas the analog 20 which has a saturated side chain showed moderate activity against KB (IC50 20.51 ?g/mL) and was inactive against the NCI-H187 cell line. Surprisingly, the sulfate derivative of 20, compound 21, was inactive to both tested cells. Compounds 29 and 31, having vicinal dihydroxy groups in ring A at C-2, C- 3 as well as a hydroxyl group at the C-20 position, showed similar activity against NCI-H187 (IC50 9.08 and 9.59 ?g/mL) but for the KB cell, only 31 showed strong activity (IC50 10.14 ?g/mL) whereas 29 was inactive. The analogue compound 37, which has an extra hydroxyl group at C-24, was inactive against both tested cell lines. |