 ผลงานตีพิมพ์ในวารสารวิชาการMolecular Dynamics of Interactions between Rigid and Flexible Antifolates and Dihydrofolate Reductase from Pyrimethamine-Sensitive and Pyrimethamine-Resistant Plasmodium falciparumผู้แต่ง: Mokmak, W, Chunsrivirot, S,  Dr.Supa Hannongbua, Professor , Yuthavong, Y, Mr.Smarn Tongsima , Kamchonwongpaisan, S, วารสาร: 
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ผลงานตีพิมพ์ในวารสารวิชาการA novel prediction approach for antimalarial activities of Trimethoprim, Pyrimethamine, and Cycloguanil analogues using extremely randomized treesผู้แต่ง:Nattee, C., Khamsemanan, N., Lawtrakul, L., Toochinda, P., Dr.Supa Hannongbua, Professor, วารสาร:  |
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ผลงานตีพิมพ์ในวารสารวิชาการKey interactions of pyrimethamine derivatives specific to wild-type and mutant P. falciparum dihydrofolate reductase based on 3D-QSAR, MD simulations and quantum chemical calculationsผู้แต่ง:Seetin, S., Dr.Patchreenart Saparpakorn, Associate Professor , Vanichtanankul, J., Vitsupakorn, D., Yuthavong, Y., Kamchonwongpaisan, S., Dr.Supa Hannongbua, Professor, วารสาร: |
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การประชุมวิชาการProven Binding Energies of Cycloguanil, Pyrimethamine and WR99210 Antifolates to PfDHFR, Based on MD/Three-Layer ONIOM Methodผู้แต่ง:พรพิมล ไมตรัตน์, วิชชา ตรีสุวรรณ, Dr.Chak Sangma, Assistant Professor , ธรรมนูญ ทวีชัย, S. Kamchonwongpaisan, ยงยุทธ ยุทธวงศ์, Dr.Supa Hannongbua, Professor, การประชุมวิชาการ: |
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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Effect of a Pyrimethamine-Sulfanilamide Combination on Induced Temporal Infertility in Male Wistar Rats) ผู้เขียน:พนัส ธรรมกีรติวงศ์, Kittiya Lerkchundhakriat สื่อสิ่งพิมพ์:pdf AbstractThe interaction of a pyrimethamine-sulfanilamide combination on the fertility of reversible infertile effects in male Wistar rats was investigated. Sample groups of rats were administered orally for 49 d based on kilograms of body weight (kgbw) as group I: 1.5 mL corn oil/d; group II: 25 mg/kgbw/d of pyrimethamine; group III: 170 mg/kgbw/d of sulfanilamide; and group IV: 25 and 170 mg/kgbw/d of combined pyrimethamine and sulfanilamide. All groups then had 35 d of drug withdrawal. Males were cohabited with untreated females to diagnose infertility on days 7, 21, 35, and 49 and reversible infertility on days 56, 70, and 84. Males were sacrificed on days 49 and 84, when spermatogram (numbers of spermatids and epididymal spermatozoa, sperm motility, viability of epididymal spermatozoa) and testicular and epididymal histopathology were examined. Male rats showed significant reductions in fertility on days 21, 35 and particularly 49 from the combined treatment, corresponding to significant impairments of spermatogram. Desquamation and multinucleated giant cells in seminiferous tubules as well as hyperplasia, degenerative and cloudy chief cells were observed in the epididymis of rats treated with the combined drugs. Infertility, spermatogram, testicular and epididymal histopathology reversibly became normal by day 35 after drug withdrawal. It was concluded that the combined administration of pyrimethamine and sulfanilamide potentiated temporal infertility effect in male Wistar rats. |
 ที่มา:JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYหัวเรื่อง:Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies |
ที่มา:มหาวิทยาลัยเกษตรศาสตร์หัวเรื่อง:Particular interaction between pyrimethamine derivatives and quadruple mutant type dihydrofolate reductase of Plasmodium falciparum: CoMFA and quantum chemical calculations studies. |
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ผลงานตีพิมพ์ในวารสารวิชาการInteractions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductasesผู้แต่ง:Maitarad, P, Kamchonwongpaisan, S, Vanichtanankul, J, Vilaivan, T, Yuthavong, Y, Dr.Supa Hannongbua, Professor, วารสาร: |
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