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 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Antimutagenicity and Anti-HSV-2 Activity of Mulberry Tea (Morus rotunbiloba Koidz)) ผู้เขียน: Thipamon Patharakorn,  นายสุลักษม์ ตาฬวัฒน์, ผู้ช่วยศาสตราจารย์ , ดร.อมรรัตน์ พรหมบุญ, รองศาสตราจารย์ , Nuanchawee Wetprasit, ดร.สุนันทา รัตนาโภ, รองศาสตราจารย์ สื่อสิ่งพิมพ์:pdf AbstractHot water extract from mulberry leaves, Morus rotunbiloba Koidz was extracted with diethyl ether, and its components were analyzed using high-pressure liquid chromatography (HPLC). Polyphenolic compounds constituted the major component (79.8%), consisting of mainly tannic acid (37.9%), epigallocatechin-3-gallate (21.1%) and caffeic acid (11.2%). The genotoxicity of the extract was evaluated by the Ames mutagenicity test, using Salmonella typhimurium strain TA 98 induced by a mutagen Trp-P-1. It was found that the number of revertant colonies was significantly decreased with an IC50 value of 4.5 mg/mL. The extract of Morus rotunbiloba Koidz also exhibited marked antiviral activity against herpes simplex virus type 2 (HSV-2) with an IC50 of 0.52 ?g/mL. The results suggested the benefit of consumption of mulberry tea for prevention of cancer and HSV-2 infection. |
หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Anti HSV-1 Activity of Spirulina platensis Polysaccharide) ผู้เขียน:Nattayaporn Chirasuwan, Ratana Chaiklahan, Marasri Ruengjitchatchawalya, Boosya Bunnag, นางมรกต ตันติเจริญ สื่อสิ่งพิมพ์:pdf AbstractAqueous extracts of Spirulina platensis were precipitated by cetyltrimethylammonium bromide (CTAB). The hot water extract was found anti Herpes simplex virus type 1 (HSV-1) activity at 50% inhibitory concentration (IC50) values of 21.32 ?g/ml. Partial purification by gel filtration of the crude extract on Sepharose 6B column gave two fractions, SHP-F1 and SHP-F2, which revealed about 4 and 2 times higher activity than that of the crude hot water extract, respectively. The crude hot water extract was a polysaccharide with rhamnose as the main sugar component. Calcium ion and sulfate groups in this polysaccharide had major roles in antiviral activity. However, the crude hot water extract polysaccharide contained approximately 42% carbohydrate and 31% protein. Decreasing the amount of protein by precipitation with trichloroacetic acid (TCA) resulted in higher purity of the crude hot water extract polysaccharide. |
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