 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Synthesis of Zn (II)-Oxazoline/Pyridine Derivative Complex as a
Molecular Sensing Ensemble for Aspartate and Histidine) ผู้เขียน: Kornvalai Panpae, Thongthawat Rerkchanchai, Thatree Wongsrichalalai สื่อสิ่งพิมพ์:pdf AbstractSynthetic receptors can readily be converted to optical chemosensors using a displacement
assay and common fluorophores and/or chromophores. Most of them are designed with covalent
attachment between a receptor and a reporter moiety. We now describe the design of spectroscopic
chemosensors bearing Zn (II) chelates with oxazoline/pyridine sites. The current progress of our use of
noncovalently attached indicators to signal binding of analytes are demonstrated. With these systems,
analyte binding which we focus on the selected amino acids, aspartate and histidine, leads to indicator
displacement from the binding cavity, which in turn yields a spectroscopic signal modulation. On the
basis of 1H NMR studies, and preliminary x-ray diffraction analysis, it is clear that Zn (II)-oxazoline/
pyridine derivative receptor cooperatively act to bind a carboxylate site of amino acids. Good agreement
of the binding affinity revealed that our receptor can colorimetrically sense aspartate higher than histidine.
In addition, it is demonstrated that careful choice of a chelating indicator with tuned affinity toward the
receptor, lower than that of the envisaged analyte, higher than that of the interferent, can provide
discrimination in sensing of a desired substrate. |