Search Result of "Samlee Mankhetkorn"

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ผลงานตีพิมพ์ในวารสารวิชาการ

Modulation of Multidrug Resistance by Artemisinin, Artesunate and Dihydroartemisinin in K562/adr and GLC4/adr Resistant Cell Lines.

ผู้แต่ง:ImgDr.Paiboon Reungpatthanaphong, Lecturer, ImgSamlee MANKHETKORN*,

วารสาร:

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ที่มา:วิทยาสารเกษตรศาสตร์ สาขา วิทยาศาสตร์

หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Cytotoxicity of Crude Proanthocyanidin Extract from Purple Glutinous Rice Bran (Oryza sativa L.) (Kum Doi Saket) Compared with Cyanidin 3-Glucoside on X63 Myeloma Cancer Cel

ผู้เขียน:ImgMontri Punyatong, ImgPuntipa Pongpiachan, ImgPetai Pongpiachan, ImgDumnern Karladee, ImgSamlee Mankhetkorn

สื่อสิ่งพิมพ์:pdf

Abstract

Proanthocyanidin and other phenolic compounds may potentially reduce the risk of cardiovascular diseases and cancer, as well as having antioxidant, anti-inflammatory and chemoprotective properties. Proanthocyanidin (PA) and cyanidin 3-glucoside (C3G), a polyphenolic compound of purple color found in purple glutinous rice (Oryza sativa L.), may also manifest these positive effects. This research evaluated the effect of PA and C3G on X63, a mouse-plasma cancer cell line of myeloma cells. PA and C3G were extracted from the purple rice bran of a local, Thailand, purple, rice genotype (Kum Doi Saket). The results showed that the amount of C3G extract from the rice genotype was 54.47 mg/ 100 g rice bran. The cytotoxicity of the crude PA extract was demonstrated by a dose-dependent decrease in the percentage cell viability of the control in the PA group. A significant difference (p<0.05) began at 100 ?g/ml and IC50 occurred at 62.29 ?g/ml. The C3G extract also exhibited a dose-dependent decrease, but the significant difference (p<0.05) began at 10 ?M and IC50 occurred at 8.4 ?M. This research demonstrated a dose-related cytotoxic effect on cancer cells by the crude PA and C3G extracts from purple glutinous rice. The results indicated the benefit of the purple rice genotypes as a functional food with potential anticancer properties.

Article Info
Agriculture and Natural Resources -- formerly Kasetsart Journal (Natural Science), Volume 042, Issue 4, Oct 08 - Dec 08, Page 676 - 681 |  PDF |  Page 

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Researcher

ดร. ไพบูลย์ เรืองพัฒนพงศ์, อาจารย์

ที่ทำงาน:ภาควิชารังสีประยุกต์และไอโซโทป คณะวิทยาศาสตร์ บางเขน

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